Purpose Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors
comprising various breast cancers simply defined by the absence of estrogen receptor …

ABSTRACT A hereditary predisposition to breast cancer significantly influences screening
and follow-up recommendations for high-risk women. However, in patients with a suggestive …

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …

Background Poly (adenosine diphosphate–ribose) polymerase inhibitors target cancers with
defects in homologous recombination repair by synthetic lethality. New therapies are …

Immunotherapy has become a mainstay of cancer treatment in many malignancies, though
its application in breast cancer remains limited. Of the breast cancer subtypes, triple …

Background Despite a remarkable increase in the depth of our understanding and
management of breast cancer in the past 50 years, the disease is still a major public health …

Context Mastectomy and sal**o-oophorectomy are widely used by carriers of BRCA1 or
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …

Breast cancer is the most frequently diagnosed cancer in women and one of the leading
causes of cancer death for women. Worldwide, over 1.3 million cases of invasive breast …

Breast cancer is a major problem for global public health. Breast Cancer is the most
common incident form of cancer in women around the world. The incidence is increasing …

Background Olaparib, a novel, orally active poly (ADP-ribose) polymerase (PARP) inhibitor,
induced synthetic lethality in BRCA-deficient cells. A maximum tolerated dose and initial …