Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues

S Yu, F Luo, Y Xu, Y Zhang, LH ** - Frontiers in Immunology, 2022 - frontiersin.org
The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

Insect immunology and hematopoiesis

JF Hillyer - Developmental & Comparative Immunology, 2016 - Elsevier
Insects combat infection by mounting powerful immune responses that are mediated by
hemocytes, the fat body, the midgut, the salivary glands and other tissues. Foreign …

Drosophila immune cells transport oxygen through PPO2 protein phase transition

M Shin, E Chang, D Lee, N Kim, B Cho, N Cha… - Nature, 2024 - nature.com
Insect respiration has long been thought to be solely dependent on an elaborate tracheal
system without assistance from the circulatory system or immune cells,. Here we describe …

Haemocyte‐mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites

I Eleftherianos, C Heryanto, T Bassal, W Zhang… - …, 2021 - Wiley Online Library
The host defence of insects includes a combination of cellular and humoral responses. The
cellular arm of the insect innate immune system includes mechanisms that are directly …

Drosophila as a Genetic Model for Hematopoiesis

U Banerjee, JR Girard, LM Goins, CM Spratford - Genetics, 2019 - academic.oup.com
In this FlyBook chapter, we present a survey of the current literature on the development of
the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of …

[HTML][HTML] Immune properties of invertebrate phenoloxidases

L Cerenius, K Söderhäll - Developmental & Comparative Immunology, 2021 - Elsevier
Melanin production from different types of phenoloxidases (POs) confers immunity from a
variety of pathogens ranging from viruses and microorganisms to parasites. The arthropod …

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

MA Hanson, A Dostálová, C Ceroni, M Poidevin… - Elife, 2019 - elifesciences.org
Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading
microorganisms. These short, cationic peptides have been implicated in many biological …

Temporal specificity and heterogeneity of Drosophila immune cells

PB Cattenoz, R Sakr, A Pavlidaki, C Delaporte… - The EMBO …, 2020 - embopress.org
Immune cells provide defense against non‐self and have recently been shown to also play
key roles in diverse processes such as development, metabolism, and tumor progression …

Natural selection has driven the recurrent loss of an immunity gene that protects Drosophila against a major natural parasite

R Arunkumar, SO Zhou, JP Day… - Proceedings of the …, 2023 - National Acad Sciences
Polymorphisms in immunity genes can have large effects on susceptibility to infection. To
understand the origins of this variation, we have investigated the genetic basis of resistance …

[HTML][HTML] More than black or white: melanization and toll share regulatory serine proteases in Drosophila

JP Dudzic, MA Hanson, I Iatsenko, S Kondo… - Cell reports, 2019 - cell.com
The melanization response is an important defense mechanism in arthropods. This reaction
is mediated by phenoloxidases (POs), which are activated by complex extracellular serine …