Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors

J Zhou, M Zaiss, L Knutsson, PZ Sun… - Magnetic resonance …, 2022 - Wiley Online Library
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain
tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially …

[HTML][HTML] Molecular imaging of brain tumors and drug delivery using CEST MRI: promises and challenges

J Huang, Z Chen, SW Park, JHC Lai, KWY Chan - Pharmaceutics, 2022 - mdpi.com
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) detects
molecules in their natural forms in a sensitive and non-invasive manner. This makes it a …

Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging

T Igarashi, H Kim, PZ Sun - NMR in Biomedicine, 2023 - Wiley Online Library
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
emerged as a novel means for sensitive detection of dilute labile protons and chemical …

Quasi–steady‐state amide proton transfer (QUASS APT) MRI enhances pH‐weighted imaging of acute stroke

PZ Sun - Magnetic resonance in medicine, 2022 - Wiley Online Library
Purpose Chemical exchange saturation transfer (CEST) imaging measurement depends not
only on the labile proton concentration and pH‐dependent exchange rate but also on …

[HTML][HTML] Fast and equilibrium CEST imaging of brain tumor patients at 3T

Y Wu, Z Liu, Q Yang, L Zou, F Zhang, L Qian, X Liu… - NeuroImage: Clinical, 2022 - Elsevier
Chemical exchange saturation transfer (CEST) MRI, versatile for detecting endogenous
mobile proteins and tissue pH, has proved valuable in tumor imaging. However, CEST MRI …

Demonstration of pH imaging in acute stroke with endogenous ratiometric chemical exchange saturation transfer magnetic resonance imaging at 2 ppm

Y Wu, PZ Sun - NMR in Biomedicine, 2023 - Wiley Online Library
Abstract pH change is often considered a hallmark of metabolic disruption in diseases such
as ischemic stroke and cancer. Chemical exchange saturation transfer (CEST) MRI …

Improving standardization and accuracy of in vivo omega plot exchange parameter determination using rotating‐frame model‐based fitting of quasi‐steady‐state Z …

JJ Chung, H Kim, Y Ji, D Lu, IY Zhou… - Magnetic Resonance in …, 2025 - Wiley Online Library
Purpose Although Ω‐plot‐driven quantification of in vivo amide exchange properties has
been demonstrated, differences in scan parameters may complicate the fidelity of …

Demonstration of fast multi‐slice quasi‐steady‐state chemical exchange saturation transfer (QUASS CEST) human brain imaging at 3T

H Kim, LC Krishnamurthy… - Magnetic resonance in …, 2022 - Wiley Online Library
Purpose To combine multi‐slice chemical exchange saturation transfer (CEST) imaging with
quasi‐steady‐state (QUASS) processing and demonstrate the feasibility of fast QUASS …

Multi-pool chemical exchange saturation transfer MRI in glioma grading, molecular subty** and evaluating tumor proliferation

H Zhu, Y Li, Y Ding, Y Liu, N Shen, Y **e, S Yan… - Journal of Neuro …, 2024 - Springer
Purpose To evaluate the performance of multi-pool Chemical exchange saturation transfer
(CEST) MRI in prediction of glioma grade, isocitrate dehydrogenase (IDH) mutation, alpha …

Deep learning to reconstruct quasi‐steady‐state chemical exchange saturation transfer from a non‐steady‐state experiment

G **ao, X Zhang, G Yang, Y Jia, G Yan… - NMR in …, 2023 - Wiley Online Library
The insufficiently long RF saturation duration and relaxation delay in chemical exchange
saturation transfer (CEST)‐MRI experiments may result in underestimation of CEST …