Determining patient's coagulation profile, ie detecting a bleeding tendency or the opposite, a
thrombotic risk, is crucial for clinicians in many situations. Routine coagulation assays and …

Thrombin is the pivotal enzyme in the biochemistry of secondary hemostasis crucial to
maintaining homeostasis of hemostasis. In contrast to routine coagulation tests (PT or aPTT) …

The release of histones from dying cells is associated with microvascular thrombosis and,
because histones activate platelets, this could represent a possible pathogenic mechanism …

INTRODUCTION: Rivaroxaban does not require monitoring nor frequent dose adjustment.
However, searching for the optimal dose in the individual patient may be useful in some …

Apixaban does not require monitoring nor frequent dose adjustment. However, searching for
the optimal dose for the individual patient may be useful in some situations. Moreover, there …

Maintaining normal hemostasis relies on a regulated system of procoagulant and
anticoagulant pathways, and disruption of these processes leads to the loss of hemostatic …

In 2018, the International Council for Standardization in Haematology (ICSH) published a
consensus document providing guidance for laboratories on measuring direct oral …

Direct oral anticoagulants (DOACs) account for most oral anticoagulant use. DOAC-
associated bleeding events are commonly encountered in clinical practice and are …

Thrombin is the central enzyme in the coagulation cascade. Estimation of an individual's
potential to generate thrombin may correlate more closely with a hyper‐or hypo‐coagulable …

The recent development of semi-automated methods has revived interest in the thrombin
generation test, a global assay that measures the overall tendency of a plasma sample to …