Gut microbiota and microbial metabolism in early risk of cardiometabolic disease

CL Gabriel, JF Ferguson - Circulation Research, 2023 - Am Heart Assoc
Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

Human genes involved in the interaction between host and gut microbiome: regulation and pathogenic mechanisms

L Boccuto, J Tack, G Ianiro, L Abenavoli, E Scarpellini - Genes, 2023 - mdpi.com
Introduction: The umbrella term “human gut microbiota” describes the complex ecosystem
harboring our gut. It includes bacteria, viruses, protozoa, archaea, fungi, and yeasts. This …

A genome-wide association study reveals the relationship between human genetic variation and the nasal microbiome

X Liu, X Tong, L Zou, Y Ju, M Liu, M Han, H Lu… - Communications …, 2024 - nature.com
The nasal cavity harbors diverse microbiota that contributes to human health and respiratory
diseases. However, whether and to what extent the host genome shapes the nasal …

Node-adaptive graph Transformer with structural encoding for accurate and robust lncRNA-disease association prediction

G Li, P Bai, C Liang, J Luo - BMC genomics, 2024 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) are integral to a plethora of critical
cellular biological processes, including the regulation of gene expression, cell …

Influence of perinatal and childhood exposure to tobacco and mercury in children's gut microbiota

S Pérez-Castro, G D'Auria, M Llambrich… - Frontiers in …, 2024 - frontiersin.org
Background Early life determinants of the development of gut microbiome composition in
infants have been widely investigated; however, if early life pollutant exposures, such as …

Early-life microbiota-immune homeostasis

HM Reynolds, ML Bettini - Frontiers in Immunology, 2023 - frontiersin.org
As the prevalence of allergy and autoimmune disease in industrialized societies continues
to rise, improving our understanding of the mechanistic roles behind microbiota-immune …

The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora's box

J Tong, Y Chen, M He, W Wang, Y Wang, N Li… - Frontiers in …, 2023 - frontiersin.org
Since the pandemic started, the coronavirus disease 2019 (COVID-19) has spread
worldwide. In patients with COVID-19, the gut microbiome (GM) has been supposed to be …

Short-chain fatty acids ameliorate imiquimod-induced skin thickening and IL-17 levels and alter gut microbiota in mice: a metagenomic association analysis

YJ Chen, HJ Ho, CH Tseng, YF Chen, ST Wang… - Scientific reports, 2024 - nature.com
Short-chain fatty acids (SCFAs) have been proposed to have anti-inflammatory effects and
improve immune homeostasis. We aimed to examine the effects of SCFAs on skin …

Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population

EM Asensio, C Ortega-Azorín, R Barragán… - Medicina, 2022 - mdpi.com
Background and Objectives: The gut microbiota has been increasingly recognized as a
relevant factor associated with metabolic diseases. However, directly measuring the …

Genome‐wide association studies: utility and limitations for research in physiology

N Pereira Ciochetti, B Lugli‐Moraes… - The Journal of …, 2023 - Wiley Online Library
Physiological systems are subject to interindividual variation encoded by genetics. Genome‐
wide association studies (GWAS) operate by surveying thousands of genetic variants from a …