The heterotrimeric guanine nucleotide-binding proteins (G proteins) act as switches that
regulate information processing circuits connecting cell surface receptors to a variety of …

In multicellular organisms from Caenorhabditis elegans to Homo sapiens, the maintenance
of homeostasis is dependent on the continual flow and processing of information through a …

G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating
guanine nucleotide exchange in the Gα subunit. To visualize this mechanism, we developed …

A subset of growth hormone-secreting human pituitary tumours carries somatic mutations
that inhibit GTPase activity of a G protein α chain, αs. The resulting activation of adenylyl …

The aim of this review is to provide a systematic overview on constitutively active G-protein-
coupled receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …

Long-term potentiation (LTP) of synaptic transmission is a widely studied model of neuronal
plasticity. The induction of LTP is known to require processes in the postsynaptic neuron …

Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) dissociate into
guanosine triphosphate (GTP)-bound α subunits and a complex of β and γ subunits after …

In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular
stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and …

Evidence suggests that both α and βγ subunits of heterotrimeric guanine nucleotide-binding
regulatory proteins (G proteins) inhibit adenylyl cyclase. Although type I adenylyl cyclase is …

The primary structure of G proteins as deduced from purified proteins and cloned subunits is
presented. When known, their functions are discussed, as are recent data on direct …