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Molecular genetics of prostate cancer: new prospects for old challenges
Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …
cancer-related mortality and morbidity in men. Since early studies on the role of the …
Prostate organogenesis: tissue induction, hormonal regulation and cell type specification
Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …
Estrogen receptors: how do they signal and what are their targets
During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …
Hedgehog: functions and mechanisms
The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
Metastatic cancers adopt certain properties of normal cells in develo** or regenerating
organs, such as the ability to proliferate and alter tissue organization. We find here that …
organs, such as the ability to proliferate and alter tissue organization. We find here that …
Hedgehog beyond medulloblastoma and basal cell carcinoma
S Teglund, R Toftgård - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2010 - Elsevier
The Hedgehog (Hh) signaling pathway is of central importance during embryo development
in metazoans and governs a diverse array of processes including cell proliferation …
in metazoans and governs a diverse array of processes including cell proliferation …
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
Prostate cancer is the most common solid tumor in men, and it shares with all cancers the
hallmark of elevated, nonhomeostatic cell proliferation. Here we have tested the hypothesis …
hallmark of elevated, nonhomeostatic cell proliferation. Here we have tested the hypothesis …
Activation of the hedgehog pathway in advanced prostate cancer
Background The hedgehog pathway plays a critical role in the development of prostate.
However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer …
However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer …
Hedgehog signaling promotes prostate xenograft tumor growth
During fetal prostate development, Sonic hedgehog (Shh) expression by the urogenital
sinus epithelium activates Gli-1 expression in the adjacent mesenchyme and promotes …
sinus epithelium activates Gli-1 expression in the adjacent mesenchyme and promotes …
Molecular signaling pathways that regulate prostate gland development
Prostate gland development is a complex process that involves coordination of multiple
signaling pathways including endocrine, paracrine, autocrine, juxtacrine and transcription …
signaling pathways including endocrine, paracrine, autocrine, juxtacrine and transcription …