Platelets and megakaryocytes are critical players in immune responses. Recent reports
suggest infection and inflammation alter the megakaryocyte and platelet transcriptome to …

Mechanisms of proteostasis in anucleate circulating platelets are unknown and may
regulate platelet function. We investigated the hypothesis that plasma–borne growth …

Protease-activated receptor 4 (PAR4)(gene F2RL3) harbors a functional dimorphism,
rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet …

In leukemia, resistance to therapy is a major concern for survival. MAPK-interacting kinases
(MNKs) have been identified as important activators of oncogenic-related signaling and may …

Background Aging is an independent risk factor for the development of cardiovascular,
thrombotic, and other chronic diseases. However, mechanisms of platelet hyperactivation in …

Cytoskeletal remodeling and mitochondrial bioenergetics play important roles in
thrombocytopoiesis and platelet function. Recently, α-actinin-1 mutations have been …

In this issue of Blood Advances, Wurtzel et al 1 report on the critical role of plasma growth
factors in the maintenance of constitutive protein translation in platelets. Their findings …

Abstract Background About 13–25% of cerebral venous thrombosis (CVT) cases lack clear
etiology, which may be associated with underlying genetic factors. This study aims to …

Thromboembolism resulting from platelet dysfunction constitutes a significant contributor to
the development of cardiovascular disease. Sirtuin 6 (SIRT6), an essential NAD+-dependent …

The pathogenesis of osteoporosis (OP) is closely associated with the disrupted balance
between osteogenesis and adipogenesis in bone marrow‐derived mesenchymal stem cells …