[HTML][HTML] Menstruation: science and society
Women's health concerns are generally underrepresented in basic and translational
research, but reproductive health in particular has been hampered by a lack of …
research, but reproductive health in particular has been hampered by a lack of …
[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …
Void‐free 3D bioprinting for in situ endothelialization and microfluidic perfusion
Two major challenges of 3D bioprinting are the retention of structural fidelity and efficient
endothelialization for tissue vascularization. Both of these issues are addressed by …
endothelialization for tissue vascularization. Both of these issues are addressed by …
Innovative human three-dimensional tissue-engineered models as an alternative to animal testing
P Bédard, S Gauvin, K Ferland, C Caneparo, È Pellerin… - Bioengineering, 2020 - mdpi.com
Animal testing has long been used in science to study complex biological phenomena that
cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it …
cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it …
Advancements in 3D cell culture systems for personalizing anti-cancer therapies
Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …
An engineered tumor-on-a-chip device with breast cancer–immune cell interactions for assessing T-cell recruitment
Recruitment of immune cells to a tumor is determined by the complex interplay between
cellular and noncellular components of the tumor microenvironment. Ex vivo platforms that …
cellular and noncellular components of the tumor microenvironment. Ex vivo platforms that …
Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes
The development of implantable neuroelectrodes is advancing rapidly as these tools are
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …
Vascularized lung cancer model for evaluating the promoted transport of anticancer drugs and immune cells in an engineered tumor microenvironment
D Kim, KS Hwang, EU Seo, S Seo… - Advanced …, 2022 - Wiley Online Library
The tumor microenvironment (TME) is the environment around the tumor, including blood
vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM) …
vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM) …
Perfusable micro-vascularized 3D tissue array for high-throughput vascular phenotypic screening
Microfluidic organ-on-a-chip technologies have enabled construction of biomimetic
physiologically and pathologically relevant models. This paper describes an injection …
physiologically and pathologically relevant models. This paper describes an injection …