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Lentiviral vector bioprocessing
C Perry, ACME Rayat - Viruses, 2021 - mdpi.com
Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …
cells and are now commonly utilised within the growing field of cell and gene therapy for the …
Zinc finger proteins: new insights into structural and functional diversity
Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their
functions are extraordinarily diverse and include DNA recognition, RNA packaging …
functions are extraordinarily diverse and include DNA recognition, RNA packaging …
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
Exosomes are released by most cells to the extracellular environment and are involved in
cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs …
cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs …
[HTML][HTML] Engineered cell entry links receptor biology with single-cell genomics
Cells communicate with each other via receptor-ligand interactions. Here, we describe
lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display …
lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display …
RNA-binding proteins: modular design for efficient function
BM Lunde, C Moore, G Varani - Nature reviews Molecular cell biology, 2007 - nature.com
Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …
of just a few basic domains that are arranged in various ways to satisfy their diverse …
The solution structure of FUS bound to RNA reveals a bipartite mode of RNA recognition with both sequence and shape specificity
FE Loughlin, PJ Lukavsky, T Kazeeva, S Reber… - Molecular cell, 2019 - cell.com
Fused in sarcoma (FUS) is an RNA binding protein involved in regulating many aspects of
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …
The RNA recognition motif, a plastic RNA‐binding platform to regulate post‐transcriptional gene expression
The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …
[HTML][HTML] TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
As key regulators in cellular functions, microRNAs (miRNAs) themselves need to be tightly
controlled. Lin28, a pluripotency factor, was reported to downregulate let-7 miRNA by …
controlled. Lin28, a pluripotency factor, was reported to downregulate let-7 miRNA by …
[HTML][HTML] Molecular basis for interaction of let-7 microRNAs with Lin28
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression.
Among these, members of the let-7 miRNA family control many cell-fate determination genes …
Among these, members of the let-7 miRNA family control many cell-fate determination genes …
Coherent two-dimensional optical spectroscopy
M Cho - Chemical reviews, 2008 - ACS Publications
Two-dimensional (2D) optical spectroscopy utilizing multiple ultrafast coherent laser pulses
in the infrared or UV-vis frequency range has been used to study protein structure and …
in the infrared or UV-vis frequency range has been used to study protein structure and …