Creutzfeldt–Jakob disease (CJD) is a rapidly progressive, fatal and transmissible
neurodegenerative disease associated with the accumulation of misfolded prion protein in …

BACKGROUND Alzheimer's disease (AD) and Parkinson's disease (PD) are the most
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …

Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …

The discovery of infectious proteins, denoted prions, was unexpected. After much debate
over the chemical basis of heredity, resolution of this issue began with the discovery that …

Creutzfeldt-Jakob disease (CJD) is a fatal disease presenting with rapidly progressive
dementia, and most patients die within a year of clinical onset. CJD poses a potential risk of …

Human prion diseases are a group of transmissible, progressive, and invariably fatal
neurodegenerative disorders, which include Kuru, Creutzfeldt-Jakob disease (CJD) …

Prion diseases are transmissible, progressive and invariably fatal neurodegenerative
conditions associated with misfolding and aggregation of a host-encoded cellular prion …

Prion disease is a neurodegenerative malady, which is believed to be transmitted via a prion
protein in its abnormal conformation (PrP Sc). Previous studies have failed to demonstrate …

It is now 18 years since the first identification of a case of vCJD in the UK. Since that time,
there has been much speculation over how vCJD might impact human health. To date there …

Abnormal prion proteins are responsible for several fatal neurodegenerative diseases in
humans and in animals, including Creutzfeldt–Jakob disease (CJD), Gerstmann–Sträussler …