Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …

It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …

Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs).
Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most …

Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin,
but how they target chromatin remains poorly understood. We have used chromatin RNA …

In biology as in real estate, location is a cardinal organizational principle that dictates the
accessibility and flow of informational traffic. An essential question in nuclear organization is …

Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

Many chromatin-binding proteins and protein complexes that regulate transcription also bind
RNA. One of these, Polycomb repressive complex 2 (PRC2), deposits the H3K27me3 mark …

Despite significant improvements during the past 3 decades, cardiovascular disease
remains a leading worldwide health epidemic. The recent identification of a fascinating …

Recently, a novel class of transcripts, long non-coding RNAs (lncRNAs), is being identified
at a rapid pace. These RNAs have critical roles in diverse biological processes, including …

Abstract Background Long non-coding RNAs (lncRNAs) have a size of more than 200 bp
and are known to regulate a host of crucial cellular processes like proliferation …