Bee updated: current knowledge on bee venom and bee envenoming therapy

MB Pucca, FA Cerni, IS Oliveira, TP Jenkins… - Frontiers in …, 2019 - frontiersin.org
Honey bees can be found all around the world and fulfill key pollination roles within their
natural ecosystems, as well as in agriculture. Most species are typically docile, and most …

Bee venom composition: From chemistry to biological activity

AA Abd El-Wahed, SAM Khalifa, BY Sheikh… - Studies in natural …, 2019 - Elsevier
Nature has provided many drugs capable of treating and alleviating human diseases.
Terrestrial plants, bacteria, insects, fungi, and bee products have played major roles in …

[HTML][HTML] Apitoxin and its components against cancer, neurodegeneration and rheumatoid arthritis: Limitations and possibilities

A Aufschnaiter, V Kohler, S Khalifa, A Abd El-Wahed… - Toxins, 2020 - mdpi.com
Natural products represent important sources for the discovery and design of novel drugs.
Bee venom and its isolated components have been intensively studied with respect to their …

Apoptotic effect of melittin purified from Iranian honey bee venom on human cervical cancer HeLa cell line

H Zarrinnahad, A Mahmoodzadeh, MP Hamidi… - International journal of …, 2018 - Springer
Melittin, an amphipathic 26-residue peptide, is the main component of honey bee venom.
Studies have been demonstrated that melittin has an inhibitory effect on proliferation of …

Standardized guidelines for Africanized honeybee venom production needed for development of new apilic antivenom

R Oliveira Orsi, R Zaluski, LC de Barros… - Journal of Toxicology …, 2024 - Taylor & Francis
Africanized bees have spread across the Americas since 1956 and consequently resulted in
human and animal deaths attributed to massive attacks related to exposure from Argentina …

Unusual reactions to hymenoptera stings: what should we keep in mind?

EÇ Mingomataj, AH Bakiri, A Ibranji… - Clinical reviews in allergy & …, 2014 - Springer
This review includes a variety of extremely rare and unusual hymenoptera sting (HS)
circumstances with regard to sting localization, geographic region, massivity of multiple …

[HTML][HTML] Phospholipase A2 enzyme from the venom of Egyptian honey bee Apis mellifera lamarckii with anti-platelet aggregation and anti-coagulation activities

DA Darwish, HMM Masoud, MM Abdel-Monsef… - Journal of Genetic …, 2021 - Elsevier
Background Honey bee venom contains various enzymes with wide medical and
pharmaceutical applications. Results The phospholipase A2 (PLA2) has been apparently …

Clinical complications in envenoming by Apis honeybee stings: insights into mechanisms, diagnosis, and pharmacological interventions

JS Cavalcante, PM Riciopo, AFM Pereira… - Frontiers in …, 2024 - frontiersin.org
Envenoming resulting from Apis honeybee stings pose a neglected public health concern,
with clinical complications ranging from mild local reactions to severe systemic …

Functional characterization of naturally occurring melittin peptide isoforms in two honey bee species, Apis mellifera and Apis cerana

D Park, JW Jung, MO Lee, SY Lee, B Kim, HJ **, J Kim… - Peptides, 2014 - Elsevier
Insect-derived antimicrobial peptides (AMPs) have diverse effects on antimicrobial
properties and pharmacological activities such as anti-inflammation and anticancer …

[HTML][HTML] Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response

AV Pereira, G Barros, EG Pinto… - Journal of Venomous …, 2016 - SciELO Brasil
Background Apis mellifera venom, which has already been recommended as an alternative
anti-inflammatory treatment, may be also considered an important source of candidate …