The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Mitochondrial Ca 2+ regulation is crucial for bioenergetics and cellular signaling. The
mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled …

Activation of Ca2+ channels in Ca2+ stores in organelles and the plasma membrane
generates cytoplasmic calcium ([Ca2+] c) signals that control almost every aspect of cell …

Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …

Mitochondrial Ca2+ (mCa2+) uptake mediated by the mitochondrial calcium uniporter
(MCU) plays a critical role in signal transduction, bioenergetics, and cell death, and its …

Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …

The mitochondrial calcium uniporter (MCU) is a highly selective calcium channel localized to
the inner mitochondrial membrane. Here, we describe the structure of an MCU orthologue …

Proper control of the mitochondrial Ca 2+ uniporter's pore (MCU) is required to allow Ca 2+-
dependent activation of oxidative metabolism and to avoid mitochondrial Ca 2+ overload …

The mitochondrial calcium uniporter complex is essential for calcium (Ca 2+) uptake into
mitochondria of all mammalian tissues, where it regulates bioenergetics, cell death, and Ca …

Identification of the sites of post-translational modifications (PTMs) in protein, RNA, and DNA
sequences is currently a very hot topic. This is because the information thus obtained is very …