Immune checkpoint blockade (ICB) therapy for cancer has achieved great success both in
clinical results and on the market. At the same time, success drives more attention from …

The dual effects of reactive oxygen species (ROS) on living organisms have become a hot
research topic in the biomedical field. Excessive ROS triggers oxidative imbalances in the …

One of the primary challenges for immune checkpoint blockade (ICB)-based therapy is the
limited infiltration of T lymphocytes (T cells) into tumors, often referred to as immunologically …

Currently, immune checkpoint blockade (ICB) therapies that target the programmed cell
death ligand-1 (PD-L1) have been used as revolutionary cancer treatments in the clinic …

The tumor microenvironment (TME) plays a key role in cancer development and emergence
of drug resistance. TME modulation has recently garnered attention as a potential approach …

Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the
loss of dopaminergic neurons within the substantia nigra. The specific molecular …

Drug therapies for acute lung injury (ALI) are far from satisfactory, primarily because drugs
cannot specifically target the lungs. Direct delivery of drugs to the deep alveolar regions by …

Low immunogenicity and immunosuppressive tumor microenvironments are major hurdles
in the application of cancer immunotherapy. To date, several immunogenic cell death (ICD) …

Proteins play a vital role in diverse biological processes in the human body, and protein
therapeutics have been applied to treat different diseases such as cancers, genetic …

Over recent years, advancements in nanomedicine have allowed new approaches to
diagnose and treat tumors. Nano drug delivery systems exploit the enhanced permeability …