Allogeneic Stem Cell Transplantation in Refractory Acute Myeloid Leukaemia

R Bono, G Sapienza, S Tringali, C Rotolo, C Patti… - Cells, 2024 - mdpi.com
Refractory acute myeloid leukaemia is very difficult to treat and represents an unmet clinical
need. In recent years, new drugs and combinations of drugs have been tested in this …

Allogeneic hematopoietic cell transplantation for older patients with AML with active disease. A study from the Acute Leukemia Working Party of the European Society …

E Maffini, M Labopin, N Kröger, J Finke… - Bone marrow …, 2024 - nature.com
Older adults with acute myeloid leukemia (AML) refractory to initial or reinduction
chemotherapy have a dismal prognosis if they do not undergo hematopoietic stem-cell …

Allogeneic hematopoietic cell transplantation for patients with acute myeloid leukemia not in remission

M Yanada, S Yamasaki, T Kondo, T Kawata, K Harada… - Leukemia, 2024 - nature.com
Allogeneic hematopoietic cell transplantation (HCT) is the last option for long-term survival
for patients with chemotherapy-refractory acute myeloid leukemia (AML). By using the …

Comparison of HLA-mismatched unrelated donor transplantation with post-transplant cyclophosphamide versus HLA-haploidentical transplantation in patients with …

F Baron, M Labopin, J Tischer, F Ciceri… - Bone Marrow …, 2022 - nature.com
HLA-haploidentical allogeneic hematopoietic stem cell transplantation (Haplo-HCT) is
frequently used as treatment for patients with active acute myeloid leukemia (AML). Here, we …

Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation

A Spyridonidis, M Labopin, T Gedde-Dahl… - Bone Marrow …, 2024 - nature.com
The intensity of the conditioning regimen given before allogeneic hematopoietic cell
transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently …

Allogeneic hematopoietic stem cell transplantation improves long-term outcome for relapsed AML patients across all ages: results from two East German Study Group …

T Heinicke, R Krahl, C Kahl, M Cross, S Scholl… - Annals of …, 2021 - Springer
Relapse of acute leukemia is a frequent complication with uncertain outcome and poorly
defined risk factors. From 1621 patients entered into two prospective clinical trials (AML02; …

Effective immunosurveillance after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

D Kunadt, F Stölzel - Cancer Management and Research, 2021 - Taylor & Francis
The number of patients receiving allogeneic hematopoietic stem cell transplantation
(alloHCT) has increased constantly over the last years due to advances in transplant …

Optimized therapeutic strategy for patients with refractory or relapsed acute myeloid leukemia: long‐term clinical outcomes and health‐related quality of life …

C Yan, Y Wang, Y Sun, Y Cheng, X Mo… - Cancer …, 2022 - Wiley Online Library
Background Patients with refractory or relapsed acute myeloid leukemia (AML) have poor
survival, necessitating the exploration of optimized therapeutic strategy. Here, we aimed to …

Early blast clearance during sequential conditioning prior to allogeneic stem cell transplantation in patients with acute myeloid leukaemia

J Ronnacker, MA Urbahn, C Reicherts… - British Journal of …, 2024 - Wiley Online Library
For patients with relapsed or refractory AML, sequential conditioning prior to allogeneic stem
cell transplantation (alloSCT) is an established and potentially curative treatment option …

Myeloablative conditioning with thiotepa-busulfan-fludarabine does not improve the outcome of patients transplanted with active leukemia: final results of the GITMO …

F Bonifazi, C Pavoni, J Peccatori, F Giglio… - Bone Marrow …, 2022 - nature.com
The outcome of refractory/relapsed (R/R) acute leukemias is still dismal and their treatment
represents an unmet clinical need. However, allogeneic transplantation (allo-HSCT) …