Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Corticobasal syndrome (CBS) is a clinical syndrome characterised by progressive
asymmetric limb rigidity and apraxia with dystonia, myoclonus, cortical sensory loss and …

This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a
wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) …

A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve
the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show …

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …

A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau
pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal …

Recent mechanistic and structural studies have challenged the classical tauopathy
classification approach and revealed the complexity and heterogeneity of tau pathology in …

The advent of PET ligands that bind tau pathology has enabled the quantification and
visualization of tau pathology in aging and in Alzheimer disease (AD). There is strong …

Objective Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and
neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also …

Studies supporting a strong association between tau deposition and neuronal loss,
neurodegeneration, and cognitive decline have heightened the allure of tau and tau‐related …