The R language: an engine for bioinformatics and data science

FM Giorgi, C Ceraolo, D Mercatelli - Life, 2022 - mdpi.com
The R programming language is approaching its 30th birthday, and in the last three decades
it has achieved a prominent role in statistics, bioinformatics, and data science in general. It …

Geographic and genomic distribution of SARS-CoV-2 mutations

D Mercatelli, FM Giorgi - Frontiers in microbiology, 2020 - frontiersin.org
The novel respiratory disease COVID-19 has reached the status of worldwide pandemic and
large efforts are currently being undertaken in molecularly characterizing the virus causing it …

Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infections

T Farinholt, H Doddapaneni, X Qin, V Menon, Q Meng… - BMC medicine, 2021 - Springer
Background This study aims to identify the causative strain of SARS-CoV-2 in a cluster of
vaccine breakthroughs. Vaccine breakthrough by a highly transmissible SARS-CoV-2 strain …

Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Spike mutation T478K

S Di Giacomo, D Mercatelli… - Journal of medical …, 2021 - Wiley Online Library
Several severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants have
emerged, posing a renewed threat to coronavirus disease 2019 containment and to vaccine …

Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution

M Amicone, V Borges, MJ Alves, J Isidro… - … medicine, and public …, 2022 - academic.oup.com
Background and objectives To understand how organisms evolve, it is fundamental to study
how mutations emerge and establish. Here, we estimated the rate of mutation accumulation …

[HTML][HTML] Applying the digital data and the bioinformatics tools in SARS-CoV-2 research

M Tan, J **a, H Luo, G Meng, Z Zhu - Computational and Structural …, 2023 - Elsevier
Bioinformatics has been playing a crucial role in the scientific progress to fight against the
pandemic of the coronavirus disease 2019 (COVID-19) caused by the severe acute …

Recurrent SARS-CoV-2 mutations in immunodeficient patients

SAJ Wilkinson, A Richter, A Casey, H Osman… - Virus …, 2022 - academic.oup.com
Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in
immunodeficient patients are an important source of variation for the virus but are …

Long-term evolution of SARS-CoV-2 in an immunocompromised patient with non-Hodgkin lymphoma

V Borges, J Isidro, M Cunha, D Cochicho, L Martins… - Msphere, 2021 - Am Soc Microbiol
Recent studies have shown that persistent SARS-CoV-2 infections in immunocompromised
patients can trigger the accumulation of an unusual high number of mutations with potential …

COV2Var, a function annotation database of SARS-CoV-2 genetic variation

Y Feng, J Yi, L Yang, Y Wang, J Wen… - Nucleic Acids …, 2024 - academic.oup.com
The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has resulted in the loss
of millions of lives and severe global economic consequences. Every time SARS-CoV-2 …

Nosocomial outbreak of SARS-CoV-2 in a “non-COVID-19” hospital ward: virus genome sequencing as a key tool to understand cryptic transmission

V Borges, J Isidro, F Macedo, J Neves, L Silva, M Paiva… - Viruses, 2021 - mdpi.com
Dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
healthcare institutions affects both patients and health-care workers (HCW), as well as the …