Iron chelators as a therapeutic option for Alzheimer's disease—A mini-review

OD Schreiner, TG Schreiner - Frontiers in Aging, 2023 - frontiersin.org
Neurodegenerative disorders, particularly Alzheimer's disease (AD), remain a great
challenge regarding the finding of effective treatment, one main reason being the incomplete …

Personal strategies to reduce the cardiovascular impacts of environmental exposures

LJ Bonanni, JD Newman - Circulation Research, 2024 - ahajournals.org
Ubiquitous environmental exposures increase cardiovascular disease risk via diverse
mechanisms. This review examines personal strategies to minimize this risk. With regard to …

Contaminant metals as cardiovascular risk factors: a scientific statement from the American Heart Association

GA Lamas, A Bhatnagar, MR Jones… - Journal of the …, 2023 - ahajournals.org
Exposure to environmental pollutants is linked to increased risk of cardiovascular disease.
Beyond the extensive evidence for particulate air pollution, accumulating evidence supports …

Combating lead and cadmium exposure with an orally administered chitosan-based chelating polymer

JA Howard, H Kuznietsova, N Dziubenko, A Aigle… - Scientific Reports, 2023 - nature.com
Heavy metals present a threat to human health, even at minimal concentrations within the
body. One source of exposure is due to the consumption of low-level contaminated foodstuff …

The trial to assess chelation therapy 2 (TACT2): rationale and design

GA Lamas, KJ Anstrom, A Navas-Acien, R Boineau… - American heart …, 2022 - Elsevier
Background Intravenous edetate disodium-based infusions reduced cardiovascular events
in a prior clinical trial. The Trial to Assess Chelation Therapy 2 (TACT2) will replicate the …

Baseline characteristics including blood and urine metal levels in the Trial to Assess Chelation Therapy 2 (TACT2)

A Navas-Acien, RM Santella, BR Joubert, Z Huang… - American Heart …, 2024 - Elsevier
Background The reduction in cardiovascular disease (CVD) events with edetate disodium
(EDTA) in the Trial to Assess Chelation Therapy (TACT) suggested that chelation of toxic …

Choroid plexus calcification correlates with cortical microglial activation in humans: A multimodal PET, CT, MRI study

T Butler, XH Wang, GC Chiang, Y Li, L Zhou… - American Journal of …, 2023 - ajnr.org
BACKGROUND AND PURPOSE: The choroid plexus (CP) within the brain ventricles is well-
known to produce cerebrospinal fluid (CSF). Recently, the CP has been recognized as …

Addressing the Missing Links in Cardiovascular Aging

E Dinetz, C Zeballos-Palacios… - Clinical Interventions in …, 2024 - Taylor & Francis
The aim of this manuscript is to provide a review of available options to enhance
cardiovascular health and prevent cardiovascular disease (CVD) in the aging population …

Environment and cardiovascular health: causes, consequences and opportunities in prevention and treatment

J Bañeras, J Iglesies-Grau, M Téllez-Plaza… - Revista Española de …, 2022 - Elsevier
The environment is a strong determinant of cardiovascular health. Environmental cardiology
studies the contribution of environmental exposures with the aim of minimizing the harmful …

Design and Synthesis of Poly (2, 2′-Bipyridyl) Ligands for Induction of Cell Death in Cancer Cells: Control of Anticancer Activity by Complexation/Decomplexation …

C Balachandran, M Hirose, T Tanaka, JJ Zhu… - Inorganic …, 2023 - ACS Publications
Chelation therapy is a medical procedure for removing toxic metals from human organs and
tissues and for the treatment of diseases by using metal-chelating agents. For example, iron …