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How to sensitize glioblastomas to temozolomide chemotherapy: A gap-centered view
Temozolomide (TMZ) is a methylating agent used as the first-line drug in the chemotherapy
of glioblastomas. However, cancer cells eventually acquire resistance, necessitating the …
of glioblastomas. However, cancer cells eventually acquire resistance, necessitating the …
Defective transfer of parental histone decreases frequency of homologous recombination by increasing free histone pools in budding yeast
Recycling of parental histones is an important step in epigenetic inheritance. During DNA
replication, DNA polymerase epsilon subunit DPB3/DPB4 and DNA replication helicase …
replication, DNA polymerase epsilon subunit DPB3/DPB4 and DNA replication helicase …
A tale of two strands: Decoding chromatin replication through strand-specific sequencing
Z Li, Z Zhang - Molecular Cell, 2025 - cell.com
DNA replication, a fundamental process in all living organisms, proceeds with continuous
synthesis of the leading strand by DNA polymerase ε (Pol ε) and discontinuous synthesis of …
synthesis of the leading strand by DNA polymerase ε (Pol ε) and discontinuous synthesis of …
Parental histone distribution and location of the replication obstacle at nascent strands control homologous recombination
C González-Garrido, F Prado - Cell Reports, 2023 - cell.com
The advance and stability of replication forks rely on a tight co-regulation of DNA synthesis
and nucleosome assembly. We show that mutants affected in parental histone recycling are …
and nucleosome assembly. We show that mutants affected in parental histone recycling are …
The loss of DNA polymerase epsilon accessory subunits POLE3–POLE4 leads to BRCA1-independent PARP inhibitor sensitivity
The clinical success of PARP1/2 inhibitors (PARPi) prompts the expansion of their
applicability beyond homologous recombination deficiency. Here, we demonstrate that the …
applicability beyond homologous recombination deficiency. Here, we demonstrate that the …
[HTML][HTML] The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity
At the core of cellular life lies a carefully orchestrated interplay of DNA replication,
recombination, chromatin assembly, sister-chromatid cohesion and transcription. These …
recombination, chromatin assembly, sister-chromatid cohesion and transcription. These …
The silent guardian: Unraveling the roles of H3K9me3 in genome maintenance
Z Li, Z Zhang - Genome Instability & Disease, 2024 - Springer
Genomic integrity is a fundamental prerequisite for all living organisms, ensuring the
accurate transmission of genetic information and stability of cellular functions across …
accurate transmission of genetic information and stability of cellular functions across …
Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase
DNA damage tolerance (DDT), activated by replication stress during genome replication, is
mediated by translesion synthesis and homologous recombination (HR). Here we uncover …
mediated by translesion synthesis and homologous recombination (HR). Here we uncover …
Overcoming drug resistance: targeting the BCL-2 family and the long non-coding RNA HCP5 in medulloblastoma and colorectal cancer
A Iseghohimen - 2023 - salford-repository.worktribe.com
Colorectal cancer (CRC) is one of the most common cancers in the UK and
medulloblastoma is a common cancer found in children. While there has been a progressive …
medulloblastoma is a common cancer found in children. While there has been a progressive …
Defective transfer of parental histone decreases frequency of homologous recombination in budding yeast
Recycling of parental histones is an important step in epigenetic inheritance. During DNA
replication, DNA polymerase epsilon subunit DPB3/DPB4 and DNA replication helicase …
replication, DNA polymerase epsilon subunit DPB3/DPB4 and DNA replication helicase …