Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …

MicroRNAs (miRNAs) play a critical role in regulating various biological processes, such as
cell differentiation and immune modulation by binding to their target genes. miR-223 is a …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

MicroRNAs, the non-coding single-stranded RNA of 19–25 nucleotides are emerging as
robust players of gene regulation. Plethora of evidences support that the ability of …

Gliomas are heterogeneous tumours derived from glial cells and remain the deadliest form
of brain cancer. Although the glioma stem cell sits at the apex of the cellular hierarchy, how it …

Lineage progression and diversification is regulated by the coordinated action of unique
sets of transcription factors. Oligodendrocytes (OL) and astrocytes (AS) comprise the glial …

Inflammation has a crucial role in protection against various pathogens. The inflammasome
is an intracellular multiprotein signaling complex that is linked to pathogen sensing and …

Disruptions to developmental cell signaling pathways and transcriptional cascades have
been implicated in tumor initiation, maintenance and progression. Resurgence of aberrant …

Abstract Central Nervous System malignancies often require stereotactic biopsy or biopsy
for differential diagnosis, and for tumor staging and grading. Furthermore, stereotactic biopsy …

Atherosclerosis is universally recognized as a chronic lipid-induced inflammation of the
vessel wall in response to dyslipidemia and haemodynamic stress involving dysfunction and …