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Potential role of DNA methylation as a driver of plastic responses to the environment across cells, organisms, and populations
There is great interest in exploring epigenetic modifications as drivers of adaptive
organismal responses to environmental change. Extending this hypothesis to populations …
organismal responses to environmental change. Extending this hypothesis to populations …
Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species
Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …
implicated in various regulatory mechanisms across the animal kingdom and particularly in …
Effects of developmental hypoxia on the vertebrate cardiovascular system
Developmental hypoxia has profound and persistent effects on the vertebrate cardiovascular
system, but the nature, magnitude, and long-term outcome of the hypoxic consequences are …
system, but the nature, magnitude, and long-term outcome of the hypoxic consequences are …
Age prediction of green turtles with an epigenetic clock
Age is a fundamental life history attribute that is used to understand the dynamics of wild
animal populations. Unfortunately, most animals do not have a practical or nonlethal method …
animal populations. Unfortunately, most animals do not have a practical or nonlethal method …
Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity
Background Epigenetic processes are proposed to be a mechanism regulating gene
expression during phenotypic plasticity. However, environmentally induced changes in DNA …
expression during phenotypic plasticity. However, environmentally induced changes in DNA …
A neural network-based model framework for cell-fate decisions and development
Gene regulatory networks (GRNs) fulfill the essential function of maintaining the stability of
cellular differentiation states by sustaining lineage-specific gene expression, while driving …
cellular differentiation states by sustaining lineage-specific gene expression, while driving …
Developmental plasticity of the cardiovascular system in oviparous vertebrates: effects of chronic hypoxia and interactive stressors in the context of climate change
Animals at early life stages are generally more sensitive to environmental stress than adults.
This is especially true of oviparous vertebrates that develop in variable environments with …
This is especially true of oviparous vertebrates that develop in variable environments with …
The integrative biology of the heart: mechanisms enabling cardiac plasticity
Cardiac phenotypic plasticity, the remodelling of heart structure and function, is a response
to any sustained (or repeated) stimulus or stressor that results in a change in heart …
to any sustained (or repeated) stimulus or stressor that results in a change in heart …
Developmental programming of sarcoplasmic reticulum function improves cardiac anoxia tolerance in turtles
Oxygen deprivation during embryonic development can permanently remodel the vertebrate
heart, often causing cardiovascular abnormalities in adulthood. While this phenomenon is …
heart, often causing cardiovascular abnormalities in adulthood. While this phenomenon is …
Exploring cytochrome P450 under hypoxia: potential pharmacological significance in drug metabolism and protection against high-altitude diseases
Q Wang, G Liu, Y Duan, D Duo, J Zhu, X Li - Drug Metabolism and …, 2024 - Elsevier
Abstracts High-altitude hypoxia affects the human respiratory, central nervous,
cardiovascular, and endocrine systems. These outcomes affect the expression of …
cardiovascular, and endocrine systems. These outcomes affect the expression of …