Abstract The Food and Drug Administration (FDA) regulates pharmaceutical drug products
to ensure a continuous supply of high-quality drugs in the USA. Continuous processing has …

Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …

For the past decade, the pharmaceutical industry has been under pressure to improve
efficiency, as rising costs outpaced the development of new pharmaceuticals.[1] A growing …

L-Asparaginase (ASNase) is a vital component of the first line treatment of acute
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …

Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …

The pharmaceutical industry has witnessed exponential growth in transforming operations
towards continuous manufacturing to increase profitability, reduce waste and extend product …

The development and operation of the synthesis and workup steps of a fully integrated,
continuous manufacturing plant for synthesizing aliskiren, a small molecule pharmaceutical …

The design of an effective plant‐wide control strategy is a key challenge for the development
of future continuous pharmaceutical processes. This article presents a case study for the …

This paper considers the model predictive control (MPC) of critical quality attributes (CQAs)
of products in an end-to-end continuous pharmaceutical manufacturing pilot plant, which …

Continuous manufacturing offers potential opportunities for the improved manufacturing of
pharmaceutical products. A key challenge is the development of an appropriate control …