The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …

Innate immunity is a semi‐specific and widely distributed form of immunity, which represents
the first line of defence against pathogens. This type of immunity is critical to maintain …

Today, cancer treatment is one of the fundamental problems facing clinicians and
researchers worldwide. Efforts to find an excellent way to treat this illness continue, and new …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Common cytokine receptor γ-chain (γc) family cytokines have crucial roles in the
development, proliferation, survival and differentiation of multiple cell lineages of both the …

T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of …

During T cell–dependent responses, B cells can either differentiate extrafollicularly into short-
lived plasma cells or enter follicles to form germinal centers (GCs). Interactions with T …

T helper (TH) cells constitute an important arm of the adaptive immune system because they
coordinate defence against specific pathogens, and their unique cytokines and effector …