Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …

In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

The germline mutation rate determines the pace of genome evolution and is an evolving
parameter itself. However, little is known about what determines its evolution, as most …

Single-nucleotide variants (SNVs) in segmental duplications (SDs) have not been
systematically assessed because of the limitations of map** short-read sequencing data …

Despite the important role that monozygotic twins have played in genetics research, little is
known about their genomic differences. Here we show that monozygotic twins differ on …

Mutations in the germline generates all evolutionary genetic variation and is a cause of
genetic disease. Parental age is the primary determinant of the number of new germline …

Meiotic recombination commences with hundreds of programmed DNA breaks; however, the
degree to which they are accurately repaired remains poorly understood. We report that …

Effects of radiation exposure from the Chernobyl nuclear accident remain a topic of interest.
We investigated germline de novo mutations (DNMs) in children born to parents employed …

The substantial phenotypic heterogeneity in autism limits our understanding of its genetic
etiology. To address this gap, here we investigated genetic differences between autistic …

The number of de novo mutations (DNMs) found in an offspring's genome increases with
both paternal and maternal age. But does the rate of mutation accumulation in human …