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Treating menopause—MHT and beyond
Every woman who lives past midlife will experience menopause, which, by definition, is
complete cessation of ovarian function. This process might occur spontaneously (natural …
complete cessation of ovarian function. This process might occur spontaneously (natural …
The menopause transition: signs, symptoms, and management options
Context Menopause, the permanent cessation of menses, reflects oocyte depletion and loss
of gonadal steroids. It is preceded by a transition state, the perimenopause, which is …
of gonadal steroids. It is preceded by a transition state, the perimenopause, which is …
Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study
Background Neurokinin 3 receptor antagonists are potential non-hormonal therapies for the
treatment of vasomotor symptoms in menopausal women as options are scarce for those …
treatment of vasomotor symptoms in menopausal women as options are scarce for those …
Drug repurposing: progress, challenges and recommendations
Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …
development, repurposing of'old'drugs to treat both common and rare diseases is …
[HTML][HTML] Safety of fezolinetant for vasomotor symptoms associated with menopause: a randomized controlled trial
OBJECTIVE: To evaluate the safety, tolerability, and effect of fezolinetant on endometrial
health over 52 weeks. METHODS: We conducted a phase 3, randomized, double-blind, 52 …
health over 52 weeks. METHODS: We conducted a phase 3, randomized, double-blind, 52 …
Hormones and aging: an endocrine society scientific statement
Multiple changes occur across various endocrine systems as an individual ages. The
understanding of the factors that cause age-related changes and how they should be …
understanding of the factors that cause age-related changes and how they should be …
Hormone therapy in menopause: concepts, controversies, and approach to treatment
Hormone therapy (HT) is an effective treatment for menopausal symptoms, including
vasomotor symptoms and genitourinary syndrome of menopause. Randomized trials also …
vasomotor symptoms and genitourinary syndrome of menopause. Randomized trials also …
Elinzanetant for the treatment of vasomotor symptoms associated with menopause: OASIS 1 and 2 randomized clinical trials
Importance Safe and effective nonhormonal treatments for menopausal vasomotor
symptoms (VMS) are needed. Objective To evaluate the efficacy and safety of elinzanetant …
symptoms (VMS) are needed. Objective To evaluate the efficacy and safety of elinzanetant …
[HTML][HTML] Efficacy and safety of elinzanetant, a selective neurokinin-1, 3 receptor antagonist for vasomotor symptoms: a dose-finding clinical trial (SWITCH-1)
Objective Neurokinin (NK)-3 and NK-1 receptors have been implicated in the etiology of
vasomotor symptoms (VMS) and sleep disturbances associated with menopause. This …
vasomotor symptoms (VMS) and sleep disturbances associated with menopause. This …
The emerging therapeutic potential of kisspeptin and neurokinin B
B Patel, K Koysombat, EG Mills, J Tsoutsouki… - Endocrine …, 2024 - academic.oup.com
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …