Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …

For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

Gene therapy holds great potential for treating almost any disease by gene silencing, protein
expression, or gene correction. To efficiently deliver the nucleic acid payload to its target …

Nanosized objects, such as nanoparticles and other drug carriers used in nanomedicine,
once in contact with biological environments are modified by adsorption of biomolecules on …

Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors
for decades with the advantages of excellent biodegradability, biocompatibility, and high …

The modification of targeting ligands on nanoparticles (NPs) is anticipated to enhance the
delivery of therapeutics to diseased tissues. However, once exposed to the blood stream …

The success of personalized medicine in oncology relies on using highly effective and
precise therapeutic modalities such as small interfering RNA (siRNA) and monoclonal …

Lipid nanoparticle (LNP) formulations are a proven method for the delivery of nucleic acids
for gene therapy as exemplified by the worldwide rollout of LNP-based RNAi therapeutics …

Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability
to deliver drugs to reach their destination more effectively due to their unique properties and …

Once introduced into physiological environment, nanoparticles (NPs) are immediately
coated with proteins, resulting in formation of what is known as protein corona. The …