There is a continued desire in biomedical research to reduce the number and duration of
design cycles required to optimize lead compounds into high-quality chemical probes or …

Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery,
filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique …

Optimizing a candidate molecule's physiochemical and functional properties has been a
critical task in drug and material design. Although the non-trivial task of balancing multiple …

A reagent-free intramolecular dehydrogenative C–N cross-coupling reaction has been
developed under mild electrolytic conditions. In this atom-and step-economical one-pot …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

Abstract BACKGROUND 1, 2, 4‐Triazolo [4, 3‐a] pyridine derivatives represent a new series
of compounds that possess good herbicidal activity against Echinochloa crusgalli (L.) …

The merging of photoredox and transition‐metal catalysis has become one of the most
attractive approaches for carbon–carbon bond formation. Such reactions require the use of …

Pyridine and pyridine-fused ring systems are ubiquitous in medicinal research and
demonstrate such diverse pharmacological benefits as anticonvulsant therapies, treatment …

Understanding and minimizing oxidative metabolism of aromatic compounds is a key hurdle
in lead optimization. Metabolic processes not only clear compounds from the body, but they …

Activation of G protein-coupled receptors (GPCRs) is an allosteric process. It involves
conformational coupling between the orthosteric ligand binding site and the G protein …