Nde1 and Ndel1: outstanding mysteries in dynein-mediated transport
SR Garrott, JP Gillies, ME DeSantis - Frontiers in Cell and …, 2022 - frontiersin.org
Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular
motor in most eukaryotes. As such, dynein has a broad array of functions that range from …
motor in most eukaryotes. As such, dynein has a broad array of functions that range from …
Mechanisms underlying the role of DISC1 in synaptic plasticity
Abstract Disrupted in schizophrenia 1 (DISC1) is an important hub protein, forming
multimeric complexes by self‐association and interacting with a large number of synaptic …
multimeric complexes by self‐association and interacting with a large number of synaptic …
Nde1 promotes Lis1-mediated activation of dynein
Cytoplasmic dynein drives the motility and force generation functions towards the
microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an …
microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an …
Ndel1 disfavors dynein–dynactin–adaptor complex formation in two distinct ways
SR Garrott, JP Gillies, A Siva, SR Little… - Journal of Biological …, 2023 - ASBMB
Dynein is the primary minus-end-directed microtubule motor protein. To achieve activation,
dynein binds to the dynactin complex and an adaptor to form the" activated dynein complex." …
dynein binds to the dynactin complex and an adaptor to form the" activated dynein complex." …
A study into the collision-induced dissociation (CID) behavior of cross-linked peptides
Cross-linking/mass spectrometry resolves protein–protein interactions or protein folds by
help of distance constraints. Cross-linkers with specific properties such as isotope-labeled or …
help of distance constraints. Cross-linkers with specific properties such as isotope-labeled or …
Structural basis for microtubule recognition by the human kinetochore Ska complex
MA Abad, B Medina, A Santamaria, J Zou… - Nature …, 2014 - nature.com
The ability of kinetochores (KTs) to maintain stable attachments to dynamic microtubule
structures ('straight'during microtubule polymerization and 'curved'during microtubule …
structures ('straight'during microtubule polymerization and 'curved'during microtubule …
NDE1 and NDEL1 from genes to (mal) functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness
Abstract NDE1 (Nuclear Distribution Element 1, also known as NudE) and NDEL1 (NDE-
Like 1, also known as NudEL) are the mammalian homologues of the fungus nudE gene …
Like 1, also known as NudEL) are the mammalian homologues of the fungus nudE gene …
Adult cortical plasticity depends on an early postnatal critical period
SD Greenhill, K Juczewski, AM De Haan, G Seaton… - Science, 2015 - science.org
Development of the cerebral cortex is influenced by sensory experience during distinct
phases of postnatal development known as critical periods. Disruption of experience during …
phases of postnatal development known as critical periods. Disruption of experience during …
Increasing the depth of mass-spectrometry-based structural analysis of protein complexes through the use of multiple cross-linkers
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is a powerful
tool to study protein folding and to map the interfaces between interacting proteins. The most …
tool to study protein folding and to map the interfaces between interacting proteins. The most …
Dendrite arborization requires the dynein cofactor NudE
AL Arthur, SZ Yang, AM Abellaneda… - Journal of Cell …, 2015 - journals.biologists.com
The microtubule-based molecular motor dynein is essential for proper neuronal
morphogenesis. Dynein activity is regulated by cofactors, and the role (s) of these cofactors …
morphogenesis. Dynein activity is regulated by cofactors, and the role (s) of these cofactors …