Hydrogels represent 3D polymeric networks specially designed for various medical
applications. Due to their porous structure, they are able to swollen and to entrap large …

Articular cartilage is a highly organized tissue that provides remarkable load-bearing and
low friction properties, allowing for smooth movement of diarthrodial joints; however, due to …

Biomedical devices comprise a major component of modern medicine, however immune-
mediated fibrosis and rejection can limit their function over time. Here, we describe a …

Cartilage regeneration remains difficult due to a lack of blood vessels. Degradation of the
extracellular matrix (ECM) causes cartilage defects, and the ECM provides the natural …

Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …

Tissue engineering holds great promise in the generation of cartilage analogues for
cartilage injury repair and replacement. However, for a long time, a variety of issues have …

Significance: Cartilage regeneration remains a significant challenge in the field of
regenerative medicine. Acellular matrix (AM)-based cartilage tissue regeneration offers an …

The humanization of animals is a powerful tool for the exploration of human disease
pathogenesis in biomedical research, as well as for the development of therapeutic …

Five agarose types (D1LE, D2LE, LM, MS8 and D5) were evaluated in tissue engineering
and compared for the first time using an array of analysis methods. Acellular and cellular …

Articular cartilage is built by chondrocytes which become less active with age. This declining
function of the chondrocytes, together with the avascular nature of the cartilage, impedes the …