Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …

The genetic architecture of autism spectrum disorder involves the interplay of common and
rare variants and their impact on hundreds of genes. Using exome sequencing, here we …

Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates
represent a substantial public health crisis that exacts tremendous personal and financial …

Depression and anxiety disorders are more prevalent in females, but the majority of
research in animal models, the first step in finding new treatments, has focused …

Opioid use kills tens of thousands of Americans each year, devastates families and entire
communities, and cripples the health care system. Exposure to opioids causes long-term …

Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter
transcriptional programs believed to promote long-lasting synaptic and behavioral …

Opioid use disorder (OUD) looms as one of the most severe medical crises facing society.
More effective therapeutics will require a deeper understanding of molecular changes …

Highlights•Chronic drug use alters the epigenetic state of neurons and other cell types within
brain reward regions.•Epigenetic adaptations are correlated with addiction, but their causal …

Abstract β-catenin is a multi-functional protein that has an important role in the mature
central nervous system; its dysfunction has been implicated in several neuropsychiatric …