Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood
although apoptosis has been proposed as a key mechanism. We now show that caspase-3 …
although apoptosis has been proposed as a key mechanism. We now show that caspase-3 …
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for …
F Bachelerie, A Ben-Baruch, AM Burkhardt… - Pharmacological …, 2014 - Elsevier
Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
EA Berger, PM Murphy, JM Farber - Annual review of …, 1999 - annualreviews.org
▪ Abstract In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …
Chemokines and leukocyte traffic
M Baggiolini - Nature, 1998 - nature.com
Over the past ten years, numerous chemokines have been identified as attractants of
different types of blood leukocytes to sites of infection and inflammation. They are produced …
different types of blood leukocytes to sites of infection and inflammation. They are produced …
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1
EJ Platt, K Wehrly, SE Kuhmann, B Chesebro… - Journal of …, 1998 - Am Soc Microbiol
It has been proposed that changes in cell surface concentrations of coreceptors may control
infections by human immunodeficiency virus type 1 (HIV-1), but the mechanisms of …
infections by human immunodeficiency virus type 1 (HIV-1), but the mechanisms of …
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4-and SDF-1-deficient mice
Q Ma, D Jones, PR Borghesani… - Proceedings of the …, 1998 - National Acad Sciences
The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte
and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1 …
and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1 …
T-cell function and migration—two sides of the same coin
Since the pioneering work of Gowans and colleagues in the 1960s, 1, 2 much progress has
been made in understanding the pivotal role of cell migration in immunity. We now have …
been made in understanding the pivotal role of cell migration in immunity. We now have …
Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
C Martin, PCE Burdon, G Bridger, JC Gutierrez-Ramos… - Immunity, 2003 - cell.com
In this study we provide evidence that the SDF-1α/CXCR4 chemokine axis is involved in
both the retention of neutrophils within the bone marrow and the homing of senescent …
both the retention of neutrophils within the bone marrow and the homing of senescent …