Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is
unknown. Here, we find that sedentary but not active humans display an age-related decline …

The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner
mitochondrial membrane, is crucial for adapting mitochondrial function and preserving …

The process of mitochondrial dynamics is emerging as a core player in cardiovascular
homeostasis. This process refers to the co‐ordinated cycles of biogenesis, fusion, fission …

The maintenance of mitochondrial DNA (mtDNA) depends on a number of nuclear gene-
encoded proteins including a battery of enzymes forming the replisome needed to …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Alzheimer's disease (AD) is characterized by the progressive degeneration of neuronal
cells. With the increase in aged population, there is a prevalence of irreversible …

Mitochondria are dynamic organelles that undergo fusion and fission. These active
processes occur continuously and simultaneously and are mediated by nuclear-DNA …