EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer. Part II—2020 update: treatment of relapsing and metastatic prostate cancer

P Cornford, RCN van den Bergh, E Briers… - European urology, 2021 - Elsevier
Objective To present a summary of the 2020 version of the European Association of Urology
(EAU)-European Association of Nuclear Medicine (EANM)-European Society for …

Update on systemic prostate cancer therapies: management of metastatic castration-resistant prostate cancer in the era of precision oncology

P Nuhn, JS De Bono, K Fizazi, SJ Freedland, M Grilli… - European urology, 2019 - Elsevier
Context Introduction of novel agents for the management of advanced prostate cancer
provides a range of treatment options with notable benefits for men with metastatic castration …

Darolutamide and survival in metastatic, hormone-sensitive prostate cancer

MR Smith, M Hussain, F Saad, K Fizazi… - … England Journal of …, 2022 - Mass Medical Soc
Background Darolutamide is a potent androgen-receptor inhibitor that has been associated
with increased overall survival among patients with nonmetastatic, castration-resistant …

Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

N Pernigoni, E Zagato, A Calcinotto, M Troiani… - Science, 2021 - science.org
The microbiota comprises the microorganisms that live in close contact with the host, with
mutual benefit for both counterparts. The contribution of the gut microbiota to the emergence …

Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration

W Abida, A Patnaik, D Campbell, J Shapiro… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE BRCA1 or BRCA2 (BRCA) alterations are common in men with metastatic
castration-resistant prostate cancer (mCRPC) and may confer sensitivity to poly (ADP …

E-PSMA: the EANM standardized reporting guidelines v1. 0 for PSMA-PET

F Ceci, DE Oprea-Lager, L Emmett, JA Adam… - European journal of …, 2021 - Springer
Rationale The development of consensus guidelines for interpretation of Prostate-Specific
Membrane Antigen (PSMA)-Positron Emission Tomography (PET) is needed to provide …

Survival with olaparib in metastatic castration-resistant prostate cancer

M Hussain, J Mateo, K Fizazi, F Saad… - … England Journal of …, 2020 - Mass Medical Soc
Background We previously reported that olaparib led to significantly longer imaging-based
progression-free survival than the physician's choice of enzalutamide or abiraterone among …

Niraparib in patients with metastatic castration-resistant prostate cancer and DNA repair gene defects (GALAHAD): a multicentre, open-label, phase 2 trial

MR Smith, HI Scher, S Sandhu, E Efstathiou… - The Lancet …, 2022 - thelancet.com
Background Metastatic castration-resistant prostate cancers are enriched for DNA repair
gene defects (DRDs) that can be susceptible to synthetic lethality through inhibition of PARP …

Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial

CC Parker, NW Clarke, AD Cook, HG Kynaston… - The Lancet, 2020 - thelancet.com
Background The optimal timing of radiotherapy after radical prostatectomy for prostate
cancer is uncertain. We aimed to compare the efficacy and safety of adjuvant radiotherapy …

Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival …

K Fizazi, NP Tran, L Fein, N Matsubara… - The Lancet …, 2019 - thelancet.com
Background In the interim analyses of the LATITUDE study, the addition of abiraterone
acetate plus prednisone to androgen deprivation therapy (ADT) led to a significant …