PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs
C Wang, H Lin - Genome Biology, 2021 - Springer
PIWI proteins, a subfamily of PAZ/PIWI Domain family RNA-binding proteins, are best known
for their function in silencing transposons and germline development by partnering with …
for their function in silencing transposons and germline development by partnering with …
Towards targeting Transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
The biogenesis and functions of piRNAs in human diseases
X Wu, Y Pan, Y Fang, J Zhang, M **e, F Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …
Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans
In the fetal mouse testis, PIWI-interacting RNAs (piRNAs) guide PIWI proteins to silence
transposons but, after birth, most post-pubertal pachytene piRNAs map to the genome …
transposons but, after birth, most post-pubertal pachytene piRNAs map to the genome …
Non-coding RNAs: long non-coding RNAs and microRNAs in endocrine-related cancers
CM Klinge - Endocrine-related cancer, 2018 - erc.bioscientifica.com
The human genome is 'pervasively transcribed'leading to a complex array of non-coding
RNAs (ncRNAs) that far outnumber coding mRNAs. ncRNAs have regulatory roles in …
RNAs (ncRNAs) that far outnumber coding mRNAs. ncRNAs have regulatory roles in …
[HTML][HTML] Epigenetic regulation during primordial germ cell development and differentiation
Germline development varies significantly across metazoans. However, mammalian
primordial germ cell (PGC) development has key conserved landmarks, including a critical …
primordial germ cell (PGC) development has key conserved landmarks, including a critical …
PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
PIWI proteins and PIWI-interacting RNAs (piRNAs) suppress transposon activity in animals,
thus protecting their genomes from detrimental insertion mutagenesis. Here, we reveal that …
thus protecting their genomes from detrimental insertion mutagenesis. Here, we reveal that …
Emerging roles of PIWI-interacting RNAs (piRNAs) and PIWI proteins in head and neck cancer and their potential clinical implications
Head and neck squamous cell carcinoma (HNSCC) are among the well-known neoplasms
originating in the oral cavity, pharynx, and larynx. Despite advancements in chemotherapy …
originating in the oral cavity, pharynx, and larynx. Despite advancements in chemotherapy …
Control of LINE-1 expression maintains genome integrity in germline and early embryo development
Maintenance of genome integrity in the germline and in preimplantation embryos is crucial
for mammalian development. Epigenetic remodeling during primordial germ cell (PGC) and …
for mammalian development. Epigenetic remodeling during primordial germ cell (PGC) and …