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On the mechanistic origins of toughness in bone
ME Launey, MJ Buehler… - Annual review of materials …, 2010 - annualreviews.org
One of the most intriguing protein materials found in nature is bone, a material composed of
assemblies of tropocollagen molecules and tiny hydroxyapatite mineral crystals that form an …
assemblies of tropocollagen molecules and tiny hydroxyapatite mineral crystals that form an …
Map** structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and …
JD Parkin, JD San Antonio, V Pedchenko… - Human …, 2011 - Wiley Online Library
Collagen IV is the major protein found in basement membranes. It comprises three
heterotrimers (a1a1a2, a3a4a5, and a5a5a6) that form distinct networks, and are …
heterotrimers (a1a1a2, a3a4a5, and a5a5a6) that form distinct networks, and are …
Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up
Collagen constitutes one-third of the human proteome, providing mechanical stability,
elasticity, and strength to organisms and is the prime construction material in biology …
elasticity, and strength to organisms and is the prime construction material in biology …
Viscoelastic properties of model segments of collagen molecules
Collagen is the prime construction material in vertebrate biology, determining the
mechanical behavior of connective tissues such as tendon, bone and skin. Despite …
mechanical behavior of connective tissues such as tendon, bone and skin. Despite …
Structural and mechanical differences between collagen homo-and heterotrimers: relevance for the molecular origin of brittle bone disease
Collagen constitutes one-third of the human proteome, providing mechanical stability,
elasticity, and strength to organisms. Normal type I collagen is a heterotrimer triple-helical …
elasticity, and strength to organisms. Normal type I collagen is a heterotrimer triple-helical …
Thickness of hydroxyapatite nanocrystal controls mechanical properties of the collagen–hydroxyapatite interface
Collagen–hydroxyapatite interfaces compose an important building block of bone structures.
While it is known that the nanoscale structure of this elementary building block can affect the …
While it is known that the nanoscale structure of this elementary building block can affect the …
Coarse-grained model of collagen molecules using an extended MARTINI force field
A Gautieri, A Russo, S Vesentini… - Journal of Chemical …, 2010 - ACS Publications
Collagen is the most abundant protein in the human body, providing mechanical stability,
elasticity, and strength to connective tissues such as tendons, ligaments, and bone. Here …
elasticity, and strength to connective tissues such as tendons, ligaments, and bone. Here …
Modeling and measuring visco-elastic properties: From collagen molecules to collagen fibrils
A Gautieri, S Vesentini, A Redaelli… - International Journal of …, 2013 - Elsevier
Collagen is the main structural protein in vertebrate biology, determining the mechanical
behavior of connective tissues such as tendon, bone and skin. Although extensive efforts in …
behavior of connective tissues such as tendon, bone and skin. Although extensive efforts in …
Hydration and distance dependence of intermolecular shearing between collagen molecules in a model microfibril
In vertebrates, collagen tissues are the main component responsible for force transmission.
In spite of the physiological importance of these phenomena, force transmission …
In spite of the physiological importance of these phenomena, force transmission …
A review of combined experimental and computational procedures for assessing biopolymer structure–process–property relationships
Tailored biomaterials with tunable functional properties are desirable for many applications
ranging from drug delivery to regenerative medicine. To improve the predictability of …
ranging from drug delivery to regenerative medicine. To improve the predictability of …