On the mechanistic origins of toughness in bone

ME Launey, MJ Buehler… - Annual review of materials …, 2010 - annualreviews.org
One of the most intriguing protein materials found in nature is bone, a material composed of
assemblies of tropocollagen molecules and tiny hydroxyapatite mineral crystals that form an …

Map** structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and …

JD Parkin, JD San Antonio, V Pedchenko… - Human …, 2011 - Wiley Online Library
Collagen IV is the major protein found in basement membranes. It comprises three
heterotrimers (a1a1a2, a3a4a5, and a5a5a6) that form distinct networks, and are …

Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up

A Gautieri, S Vesentini, A Redaelli, MJ Buehler - Nano letters, 2011 - ACS Publications
Collagen constitutes one-third of the human proteome, providing mechanical stability,
elasticity, and strength to organisms and is the prime construction material in biology …

Viscoelastic properties of model segments of collagen molecules

A Gautieri, S Vesentini, A Redaelli, MJ Buehler - Matrix Biology, 2012 - Elsevier
Collagen is the prime construction material in vertebrate biology, determining the
mechanical behavior of connective tissues such as tendon, bone and skin. Despite …

Structural and mechanical differences between collagen homo-and heterotrimers: relevance for the molecular origin of brittle bone disease

SW Chang, SJ Shefelbine, MJ Buehler - Biophysical journal, 2012 - cell.com
Collagen constitutes one-third of the human proteome, providing mechanical stability,
elasticity, and strength to organisms. Normal type I collagen is a heterotrimer triple-helical …

Thickness of hydroxyapatite nanocrystal controls mechanical properties of the collagen–hydroxyapatite interface

Z Qin, A Gautieri, AK Nair, H Inbar, MJ Buehler - Langmuir, 2012 - ACS Publications
Collagen–hydroxyapatite interfaces compose an important building block of bone structures.
While it is known that the nanoscale structure of this elementary building block can affect the …

Coarse-grained model of collagen molecules using an extended MARTINI force field

A Gautieri, A Russo, S Vesentini… - Journal of Chemical …, 2010 - ACS Publications
Collagen is the most abundant protein in the human body, providing mechanical stability,
elasticity, and strength to connective tissues such as tendons, ligaments, and bone. Here …

Modeling and measuring visco-elastic properties: From collagen molecules to collagen fibrils

A Gautieri, S Vesentini, A Redaelli… - International Journal of …, 2013 - Elsevier
Collagen is the main structural protein in vertebrate biology, determining the mechanical
behavior of connective tissues such as tendon, bone and skin. Although extensive efforts in …

Hydration and distance dependence of intermolecular shearing between collagen molecules in a model microfibril

A Gautieri, MI Pate, S Vesentini, A Redaelli… - Journal of …, 2012 - Elsevier
In vertebrates, collagen tissues are the main component responsible for force transmission.
In spite of the physiological importance of these phenomena, force transmission …

A review of combined experimental and computational procedures for assessing biopolymer structure–process–property relationships

G Gronau, ST Krishnaji, ME Kinahan, T Giesa… - Biomaterials, 2012 - Elsevier
Tailored biomaterials with tunable functional properties are desirable for many applications
ranging from drug delivery to regenerative medicine. To improve the predictability of …