Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …

Fibroblast activation protein-α (FAP) is a type-II transmembrane serine protease expressed
almost exclusively to pathological conditions including fibrosis, arthritis, and cancer. Across …

The tumor microenvironment has been identified as one of the driving factors of tumor
progression and invasion. Inside this microenvironment, cancer‐associated fibroblasts …

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various
hormones and extracellular matrix components. FAP is highly upregulated in a wide variety …

Fibroblast activation protein-α (FAP) is a type II integral serine protease that is specifically
expressed by activated fibroblasts. Cancer-associated fibroblasts (CAFs) in the tumor stroma …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …

Mesenchymal stem or stromal cells (MSCs) are pluripotent cells implicated in a broad range
of physiological events, including organogenesis and maintenance of tissue homeostasis as …

Although the spatial, cellular and molecular landscapes of resected pancreatic ductal
adenocarcinoma (PDAC) are well documented, the characteristics of its metastatic ecology …

The tumour microenvironment (TME) determines vital aspects of tumour development, such
as tumour growth, metastases and response to therapy. Cancer-associated fibroblasts …

Cellular senescence is a state of permanent growth arrest that plays an important role in
wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells'(SnCs) …