The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

The microbially derived antiproliferative agent rapamycin inhibits cell growth by interfering
with the signaling functions of the mammalian target of rapamycin (mTOR). In this study, we …

Purpose: Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin
lymphoma confined to the central nervous system. Whether there is a PCNSL-specific …

Phorbol ester treatment of quiescent Swiss 3T3 cells leads to cell proliferation, a response
thought to be mediated by protein kinase C (PKC), the major cellular receptor for this class of …

Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological
processes, as highlighted in this review. An overview of how SFKs interact with, and …

The use of small-molecule inhibitors to study molecular components of cellular signal
transduction pathways provides a means of analysis complementary to currently used …

Protein kinase C (PKC), which comprises 11 closely related isoforms, has been implicated in
a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis and …

These studies demonstrate that treatment of human U-937 cells with ionizing radiation (IR) is
associated with activation of a cytoplasmic myelin basic protein (MBP) kinase …