During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Senescence is a multi‐functional cell fate, characterized by an irreversible cell‐cycle arrest
and a pro‐inflammatory phenotype, commonly known as the senescence‐associated …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Cellular senescence, a cell state characterized by a generally irreversible cell cycle arrest, is
implicated in various physiological processes and a wide range of age-related pathologies …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

Significance: Cell senescence was originally defined by an acute loss of replicative capacity
and thus believed to be restricted to proliferation-competent cells. More recently …

Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely
interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory …

Mitochondria are highly dynamic organelles and their proper function is crucial for the
maintenance of cellular homeostasis. Mitochondrial biogenesis and mitophagy are two …