Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …

A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of
ketones. While KDs improve certain health conditions and are popular for weight loss …

Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …