Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …
[HTML][HTML] Mutual regulation of metabolic processes and proinflammatory NF-κB signaling
The nuclear factor kappa B (NF-κB) signaling system, a key regulator of immunologic
processes, also affects a plethora of metabolic changes associated with inflammation and …
processes, also affects a plethora of metabolic changes associated with inflammation and …
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases
Human inborn errors of thymic T cell tolerance underlie the production of autoantibodies
(auto-Abs) neutralizing type I IFNs, which predispose to severe viral diseases. We analyze …
(auto-Abs) neutralizing type I IFNs, which predispose to severe viral diseases. We analyze …
[HTML][HTML] TGF-β/PI3K/AKT/mTOR/NF-kB pathway. Clinicopathological features in prostate cancer
N Torrealba, R Vera, B Fraile, P Martinez-Onsurbe… - The Aging …, 2020 - Taylor & Francis
Prostate cancer is one of the most common cancers in the male population. The objective of
this investigation was to study the relationship of components of transforming growth factor-B …
this investigation was to study the relationship of components of transforming growth factor-B …
[HTML][HTML] Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure
Z Zhang, Z Yang, S Wang, X Wang, J Mao - Biomedicine & …, 2024 - Elsevier
The pyroptosis of cardiomyocytes has become an essential topic in heart failure research.
The abnormal accumulation of these biological factors, including angiotensin II, advanced …
The abnormal accumulation of these biological factors, including angiotensin II, advanced …
NF-κB in hematological malignancies
V Imbert, JF Peyron - Biomedicines, 2017 - mdpi.com
NF-κB (Nuclear Factor Κ-light-chain-enhancer of activated B cells) transcription factors are
critical regulators of immunity, stress response, apoptosis, and differentiation. Molecular …
critical regulators of immunity, stress response, apoptosis, and differentiation. Molecular …
[HTML][HTML] Advanced in vitro models for renal cell carcinoma therapy design
Renal cell carcinoma (RCC) and its principal subtype, clear cell RCC, are the most
diagnosed kidney cancer. Despite substantial improvement over the last decades, current …
diagnosed kidney cancer. Despite substantial improvement over the last decades, current …
The many roles of ubiquitin in NF-κB signaling
G Courtois, MO Fauvarque - Biomedicines, 2018 - mdpi.com
The nuclear factor κB (NF-κB) signaling pathway ubiquitously controls cell growth and
survival in basic conditions as well as rapid resetting of cellular functions following …
survival in basic conditions as well as rapid resetting of cellular functions following …
[HTML][HTML] The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias
Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors plays a key role
in cancer pathogenesis due to the ability to promote cellular proliferation and survival, to …
in cancer pathogenesis due to the ability to promote cellular proliferation and survival, to …
The NF-κB Inhibitor, IMD-0354, Affects Immune Gene Expression, Bacterial Microbiota and Trypanosoma cruzi Infection in Rhodnius prolixus Midgut
CS Vieira, OC Moreira, KKS Batista… - Frontiers in …, 2018 - frontiersin.org
Rhodnius prolixus is an insect vector of Trypanosoma cruzi, the causative agent of Chagas
disease in Latin America. Nuclear factor-κ B (NF-κ B) transcription factors (TF) are conserved …
disease in Latin America. Nuclear factor-κ B (NF-κ B) transcription factors (TF) are conserved …