In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

GNAO1 disorder is a rare autosomal dominant neurodevelopmental syndrome that is
clinically manifested by developmental delay,(early onset) epilepsy, and movement …

G-protein coupled receptors (GPCRs) and ion channels serve as key molecular switches
through which extracellular stimuli are transformed into intracellular effects, and it has long …

General protein folding is mediated by chaperones that utilize ATP hydrolysis to regulate
client binding and release. Zinc-finger protein 1 (Zpr1) is an essential ATP-independent …

Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of
heterotrimeric G protein α subunits. The Ric-8A isoform chaperones Gαi/o, Gα12/13, and …

GNAO1 mutated in pediatric encephalopathies encodes the major neuronal G-protein Gαo.
Of> 80 pathogenic mutations, most are single amino acid substitutions spreading across …

ABSTRACT G protein–coupled receptors (GPCRs) couple to heterotrimeric G proteins,
comprised of α and βγ subunits, to convert extracellular signals into activation of intracellular …

GNAO1 mutated in pediatric encephalopathies encodes the major neuronal G-protein Gαo.
Of> 40 pathogenic mutations, most are single amino acid substitutions spreading across …

Heterotrimeric G proteins are classified into four subfamilies and play a key role in signal
transduction. They transmit extracellular signals to intracellular effectors subsequent to the …

Mas-related G-protein-coupled receptors X1-X4 (MRGPRX1-X4) are 4 primate-specific
receptors that are recently reported to be responsible for many biological processes …