The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Abstract Major Depressive Disorder (MDD) is an affective disorder with sustained negative
affect and difficulties experiencing positive affect as its hallmark features. Previous work also …

Depression is associated with social risk factors, social impairments and poor social
functioning. This paper gives an overview of these social aspects using the NIMH Research …

We propose that depression can be viewed as an adaptation to conserve energy after the
perceived loss of an investment in a vital resource such as a relationship, group identity, or …

Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that
purpose, has garnered marked interest over the past two decades as an emerging treatment …

The role of stress in the origin and development of depression may be conceived as the
result of multiple converging factors, including the chronic effect of environmental stressors …

This article reviews the interactions of estrogen changes and psychosocial stress in
contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Many neuroimaging studies have investigated reward processing dysfunction in major
depressive disorder. These studies have led to the common idea that major depressive …