The osteocyte as a signaling cell
Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …
Sclerostin and osteocalcin: candidate bone-produced hormones
In addition to its structural role, the skeleton serves as an endocrine organ that controls
mineral metabolism and energy homeostasis. Three major cell types in bone-osteoblasts …
mineral metabolism and energy homeostasis. Three major cell types in bone-osteoblasts …
Crosstalk between lipid metabolism and bone homeostasis: exploring intricate signaling relationships
H **ao, W Li, Y Qin, Z Lin, C Qian, M Wu, Y **a, J Bai… - Research, 2024 - spj.science.org
Bone is a dynamic tissue reshaped by constant bone formation and bone resorption to
maintain its function. The skeletal system accounts for approximately 70% of the total volume …
maintain its function. The skeletal system accounts for approximately 70% of the total volume …
Role of sclerostin in cardiovascular disease
Sclerostin is most recognized for its role in controlling bone formation but is also expressed
in the heart, aorta, coronary, and peripheral arteries. This review summarizes research on …
in the heart, aorta, coronary, and peripheral arteries. This review summarizes research on …
[HTML][HTML] A review on the crosstalk between insulin and wnt/β-catenin signalling for bone health
A positive association between insulin resistance and osteoporosis has been widely
established. However, crosstalk between the signalling molecules in insulin and Wingless …
established. However, crosstalk between the signalling molecules in insulin and Wingless …
Wnt signaling: from mesenchymal cell fate to lipogenesis and other mature adipocyte functions
Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in
the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate …
the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate …
Senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis through cyclooxygenase 2
Background: Metabolic syndrome–associated osteoarthritis (MetS-OA) is a distinct
osteoarthritis phenotype defined by the coexistence of MetS or its individual components …
osteoarthritis phenotype defined by the coexistence of MetS or its individual components …
The link between bone-derived factors osteocalcin, fibroblast growth factor 23, sclerostin, lipocalin 2 and tumor bone metastasis
M Martiniakova, V Mondockova, R Biro… - Frontiers in …, 2023 - frontiersin.org
The skeleton is the third most common site of metastatic disease, which causes serious
bone complications and short-term prognosis in cancer patients. Prostate and breast …
bone complications and short-term prognosis in cancer patients. Prostate and breast …
FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology
The rise of life expectancy of the human population is accompanied by the drastic increases
of age‐associated diseases, in particular Alzheimer's disease (AD), and underscores the …
of age‐associated diseases, in particular Alzheimer's disease (AD), and underscores the …
Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion
Z Li, B Shi, N Li, J Sun, X Zeng, R Huang, S Bok… - Nature …, 2024 - nature.com
The skeleton has been suggested to function as an endocrine organ controlling whole
organism energy balance, however the mediators of this effect and their molecular links …
organism energy balance, however the mediators of this effect and their molecular links …