Engineering immune-evasive allogeneic cellular immunotherapies

KE Martin, Q Hammer, K Perica, M Sadelain… - Nature Reviews …, 2024 - nature.com
Allogeneic cellular immunotherapies hold a great promise for cancer treatment owing to
their potential cost-effectiveness, scalability and on-demand availability. However, immune …

Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

A Grattoni, G Korbutt, AA Tomei, AJ García… - Nature Reviews …, 2024 - nature.com
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …

Current advances in immunomodulatory biomaterials for cell therapy and tissue engineering

B Kim, L Pradhan, A Hernandez… - Advanced …, 2023 - Wiley Online Library
Biomaterials have gained immense attention for various diseases due to their unique
advantages over chemical drugs regarding cost, ease of production, toxicity, and therapeutic …

Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions

L Knoedler, J Dean, F Diatta, N Thompson… - Frontiers in …, 2024 - frontiersin.org
Balancing the immune response after solid organ transplantation (SOT) and vascularized
composite allotransplantation (VCA) remains an ongoing clinical challenge. While …

Immunomodulation in Non-traditional Therapies for Methicillin-resistant Staphylococcus aureus (MRSA) Management

S Subbarayudu, SKR Namasivayam, J Arockiaraj - Current Microbiology, 2024 - Springer
The rise of methicillin-resistant Staphylococcus aureus (MRSA) poses a significant
challenge in clinical settings due to its ability to evade conventional antibiotic treatments …

Transforming stressed plants into healthy foods

L Cisneros-Zevallos, M Maghoumi… - Current Opinion in …, 2023 - Elsevier
Highlights•Stressed plants can be transformed into healthy foods.•Oxidative stress plays a
key role in nutraceutical biosynthesis.•Fresh produce, by-products, and waste can be used …

[HTML][HTML] Engineering platforms for localized long-acting immune modulation

CYX Chua, DI Viswanath, DP Huston… - Journal of Allergy and …, 2024 - Elsevier
Systemic immunotherapeutics have been a clinical staple in the treatment of cancer,
infectious diseases, organ and cell transplantation, autoimmunity, and allergies. While their …

Self‐Healing COCu‐Tac Hydrogel Enhances iNSCs Transplantation for Spinal Cord Injury by Promoting Mitophagy via the FKBP52/AKT Pathway

Z Tian, HJ Hu, CC Chan, T Hu, C Cai, H Li… - Advanced …, 2025 - Wiley Online Library
In the realm of neural regeneration post‐spinal cord injury, hydrogel scaffolds carrying
induced neural stem cells (iNSCs) have demonstrated significant potential. However …

Hydrogel-composited laminate for islet immune-isolation to treat type 1 diabetes

Y Wang, K Wang, X Wang, Y Luo… - ACS Applied Materials & …, 2024 - ACS Publications
Challenges remain to be solved for the clinical translation of β-cell encapsulation technology
in the treatment of type 1 diabetes (T1D). Successful delivery of β cells urgently needs the …

Inflammatory and Immune Mechanisms in COPD: Current Status and Therapeutic Prospects

Y Qi, Y Yan, D Tang, J Han, X Zhu, M Cui… - Journal of …, 2024 - Taylor & Francis
Background Chronic obstructive pulmonary disease (COPD) currently ranks among the top
three causes of mortality worldwide, presenting as a prevalent and complex respiratory …