Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …

The dynamic behavior of epithelial cell sheets plays a central role during numerous
developmental processes. Genetic and imaging studies of epithelial morphogenesis in a …

The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …

Morphogenesis emerges from complex multiscale interactions between genetic and
mechanical processes. To understand these processes, the evolution of cell shape …

During development, mechanical forces cause changes in size, shape, number, position,
and gene expression of cells. They are therefore integral to any morphogenetic processes …

Positional information is a central concept in developmental biology. In develo** organs,
positional information can be idealized as a local coordinate system that arises from …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

The seminal observation that mechanical signals can elicit changes in biochemical
signalling within cells, a process commonly termed mechanosensation and …

Mechanical forces have been proposed to modulate organ growth, but a molecular
mechanism that links them to growth regulation in vivo has been lacking. We report that …

Orientation of cell divisions is a key mechanism of tissue morphogenesis. In the growing
Drosophila wing imaginal disc epithelium, most of the cell divisions in the central wing …