Structural biology of CRISPR–Cas immunity and genome editing enzymes
CRISPR–Cas systems provide resistance against foreign mobile genetic elements and have
a wide range of genome editing and biotechnological applications. In this Review, we …
a wide range of genome editing and biotechnological applications. In this Review, we …
Molecular mechanisms of CRISPR-Cas immunity in bacteria
Prokaryotes have developed numerous defense strategies to combat the constant threat
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …
Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools
J Dronina, U Samukaite-Bubniene… - Journal of …, 2022 - Springer
Early detection of viral pathogens by DNA-sensors in clinical samples, contaminated foods,
soil or water can dramatically improve clinical outcomes and reduce the socioeconomic …
soil or water can dramatically improve clinical outcomes and reduce the socioeconomic …
The application of DNA polymerases and Cas9 as representative of DNA-modifying enzymes group in DNA sensor design
Rapid detection of nucleic acids (DNA or RNA) by inexpensive, selective, accurate, and
highly sensitive methods is very important for biosensors. DNA-sensors based on DNA …
highly sensitive methods is very important for biosensors. DNA-sensors based on DNA …
Comprehensive classification of ABC ATPases and their functional radiation in nucleoprotein dynamics and biological conflict systems
ABC ATPases form one of the largest clades of P-loop NTPase fold enzymes that catalyze
ATP-hydrolysis and utilize its free energy for a staggering range of functions from transport to …
ATP-hydrolysis and utilize its free energy for a staggering range of functions from transport to …
Creating memories: molecular mechanisms of CRISPR adaptation
H Lee, DG Sashital - Trends in biochemical sciences, 2022 - cell.com
Prokaryotes use clustered regularly interspaced short palindromic repeat (CRISPR) and
CRISPR-associated (Cas) proteins as an adaptive immune system. CRISPR-Cas systems …
CRISPR-associated (Cas) proteins as an adaptive immune system. CRISPR-Cas systems …
Disease-relevant β2-microglobulin variants share a common amyloid fold
Abstract β2-microglobulin (β2m) and its truncated variant ΔΝ6 are co-deposited in amyloid
fibrils in the joints, causing the disorder dialysis-related amyloidosis (DRA). Point mutations …
fibrils in the joints, causing the disorder dialysis-related amyloidosis (DRA). Point mutations …
A truncated anti-CRISPR protein prevents spacer acquisition but not interference
CRISPR-Cas systems in prokaryotic cells provide an adaptive immunity against invading
nucleic acids. For example, phage infection leads to addition of new immunity (spacer …
nucleic acids. For example, phage infection leads to addition of new immunity (spacer …
Advances and insights in the diagnosis of viral infections
Viral infections are the most common among diseases that globally require around 60
percent of medical care. However, in the heat of the pandemic, there was a lack of medical …
percent of medical care. However, in the heat of the pandemic, there was a lack of medical …
[HTML][HTML] CRISPR/Cas9 based genome editing for targeted transcriptional control in triple-negative breast cancer
Breast cancer (BC) is the most common type of cancer in women at the global level and the
highest mortality rate has been observed with triple-negative breast cancer (TNBC) …
highest mortality rate has been observed with triple-negative breast cancer (TNBC) …