Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Amyloid-β (Aβ) and tau proteins currently represent the two most promising targets to treat
Alzheimer's disease. The most extensively developed method to treat the pathologic forms of …

Hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of
frontotemporal dementia and motor neuron disease. Recently, unconventional non-ATG …

For a protein to function appropriately, it must first achieve its proper conformation and
location within the crowded environment inside the cell. Multiple chaperone systems are …

Hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of
frontotemporal dementia and motor neuron disease. One consequence of the mutation is the …

Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …

After decades of research and clinical trials there is still no cure for Alzheimer's disease
(AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the …

Amyloid is aggregated protein in the form of insoluble fibrils. Amyloid deposition in human
tissue—amyloidosis—is associated with a number of diseases including all common …

In ageing populations, neurodegenerative diseases increase in prevalence, exacting an
enormous toll on individuals and their communities. Multiple complementary experimental …