Abstract Molecular Lego: Polyketides represent a highly diverse group of natural products
with structurally intriguing carbon skeletons (see picture) which are assembled from simple …

Many thousands of small molecule natural products with interesting biological activities are
polyketides (PK), nonribosomal peptides (NRP), or hybrids thereof (ie, PK-NRP hybrids) …

Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Covering: January 1995 to June 2021 Anthracyclines are glycosylated microbial natural
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork Page 1
REVIEW www.rsc.org/npr | Natural Product Reports Type II polyketide synthases: gaining a …

Polyketide natural products constitute a broad class of compounds with diverse structural
features and biological activities. Their biosynthetic machinery, represented by type I …

Covering: up to 2012 With the recent structural characterization of each of the component
enzymes of type I polyketide synthases, scientists are coming tantalizingly close to …

Fungi produce a wide variety of biologically active compounds. Among these, the
polyketides form a large and structurally diverse group. These compounds are synthesised …

Residue pairs that directly coevolve in protein families are generally close in protein 3D
structures. Here we study the exceptions to this general trend—directly coevolving residue …