Current and novel therapies for management of Acinetobacter baumannii-associated pneumonia

AMS Shein, P Hongsing, ORK Smith… - Critical reviews in …, 2024 - Taylor & Francis
Acinetobacter baumannii is a common pathogen associated with hospital-acquired
pneumonia showing increased resistance to carbapenem and colistin antibiotics nowadays …

Cross-protection and cross-feeding between Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence

L Semenec, AK Cain, CJ Dawson, Q Liu, H Dinh… - Nature …, 2023 - nature.com
Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic pathogens
frequently co-isolated from polymicrobial infections. The infections where these pathogens …

Peptidomimetics as potential anti-virulence drugs against resistant bacterial pathogens

OF Martínez, HM Duque, OL Franco - Frontiers in Microbiology, 2022 - frontiersin.org
The uncontrollable spread of superbugs calls for new approaches in dealing with microbial-
antibiotic resistance. Accordingly, the anti-virulence approach has arisen as an attractive …

Discovery of inhibitors of Pseudomonas aeruginosa virulence through the search for natural‐like compounds with a dual role as inducers and substrates of efflux …

P Laborda, M Alcalde‐Rico, A Chini… - Environmental …, 2021 - Wiley Online Library
Multidrug efflux pumps are ancient elements encoded in every genome, from bacteria to
humans. In bacteria, in addition to antibiotics, efflux pumps extrude a wide range of …

NtrBC Regulates Invasiveness and Virulence of Pseudomonas aeruginosa During High-Density Infection

MA Alford, A Baghela, ATY Yeung, D Pletzer… - Frontiers in …, 2020 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen that is a major cause of nosocomial
and chronic infections contributing to morbidity and mortality in cystic fibrosis patients. One …

Use of adjuvants to improve antibiotic efficacy and reduce the burden of antimicrobial resistance

T Gil-Gil, P Laborda, JL Martínez… - Expert review of anti …, 2025 - Taylor & Francis
Introduction The increase in antibiotic resistance, together with the absence of novel
antibiotics, makes mandatory the introduction of novel strategies to optimize the use of …

Castaneroxy A From the Leaves of Castanea sativa Inhibits Virulence in Staphylococcus aureus

AM Salam, G Porras, YSK Cho, MM Brown… - Frontiers in …, 2021 - frontiersin.org
Methicillin-resistant Staphylococcus aureus (MRSA) represents one of the most serious
infectious disease concerns worldwide, with the CDC labeling it a “serious threat” in 2019 …

Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa

LV Wilkinson, MA Alford, SR Coleman, BC Wu… - PloS one, 2021 - journals.plos.org
Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen that causes considerable
human morbidity and mortality, particularly in nosocomial infections and individuals with …

NtrBC Selectively Regulates Host-Pathogen Interactions, Virulence, and Ciprofloxacin Susceptibility of Pseudomonas aeruginosa

MA Alford, B Baquir, A An, KYG Choi… - Frontiers in Cellular …, 2021 - frontiersin.org
Pseudomonas aeruginosa is a metabolically versatile opportunistic pathogen capable of
infecting distinct niches of the human body, including skin wounds and the lungs of cystic …